parallel synthesis of a new class of glycodendrimers

by Martin McWatt

Publisher: University of Birmingham in Birmingham

Written in English
Published: Pages: 182 Downloads: 298
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Edition Notes

Thesis (Ph.D) - University of Birmingham, School of Chemistry, Faculty of Science.

Statementby Martin Joseph McWatt.
The Physical Object
Pagination182p. :
Number of Pages182
ID Numbers
Open LibraryOL21438721M

Parallel sessions. S Chemical biology tools. OL Synthesis of a new class of thio-glycomimetics through one-pot aziridine opening reactions. P31 Synthesis of Glycodendrimers Based on a Sugar Scaffold Targeting the DC-SIGN Lectin. Laurent Cattiaux 1, Vanessa Porkolab 2. Hydrogels have emerged as a versatile class of polymeric materials with a wide range of applications in biomedical sciences. The judicious choice of hydrogel precursors allows one to introduce the necessary attributes to these materials that dictate their performance towards intended applications. Traditionally, hydrogels were fabricated using either polymerization of monomers or through Cited by: In this study, glycodendron–lipid hybrids were developed as a new and tunable class of dendritic amphiphiles. A modular synthesis was used to prepare dendron–lipid hybrids comprising distearylglycerol and 0 through 4th generation polyester dendrons with peripheral protected amines. Synthesis of Vinyl Phosphate, a Possible Intermediate in Carbohydrate Metabolism and Photosynthesis ERICH Bmn, LIUDVIKAS J. CIPLIJAUSKAS, AND TEUNIS VISSER From the Subdepartment of Synthetic Chemistry in Relation to Medical Research, Banting and Best.

Parallel synthesis of tandem Ugi/Diels–Alder reaction products on a soluble polymer support directed toward split-pool realization of a small molecule library Masato Oikawa,* Minoru Ikoma and Makoto Sasaki Laboratory of Biostructural Chemistry, Graduate School of Life Sciences, Tohoku University, Tsutsumidori-Amamiya, Aoba-ku, Sendai Human Cell Structure cell is basic unit of all life; structural and functional if its alive, must contain at least a single cell the function of an organism is the summation of functions of its individual cells in human body single fertilized egg 75– trillion cells (adult) [>10x’s more bacterial cells in body] range in size from. Boons, G. (). Parallel combinatorial synthesis of heparan sulfate derivatives for array development. G. J. (). Chemical synthesis of alpha-D-mannosylphosphate serine derivatives: A new class of synthetic glycopeptides. & Boons, G. J. (). Parallel combinatorial synthesis of glycodendrimers and their hydrogelation properties. Mar 13,  · Cells are decorated with charged and uncharged carbohydrate ligands known as glycans, which are responsible for several key functions, including their interactions with proteins known as lectins. Here, a platform consisting of synthetic nanoscale vesicles, known as glycodendrimersomes, which can be programmed with cell surface-like structural and topological complexity, is employed to dissect Cited by:

Glycoconjugates: Composition: Structure, and Function - CRC Press Book × Close Your instructor credentials will not grant access to the Hub, but existing and new users may request access here. The student resources previously accessed via are no longer available to existing or new users. In the divergent approach, firstly the synthesis of the functionalized core (or inner part of the dendrimer) takes part. Then this structure serves as a scaffold for the synthesis of higher generation dendrimers. Convergent approach relies on the synthesis of dendrons, which can be further attached to the earlier synthesized by: 2. Solid-Phase Synthesis of Multivalent Glycoconjugates on a DNA Synthesizer Michael Dubber and Jean M. J. Fre´chet* Department of Chemistry, University of California, Berkeley, California Received October 9, Carbohydrate-oligonucleotide conjugates and glycodendrimers were synthesized utilizing a DNA synthesizer. the natural product, 48 While recent advances in the chemical synthesis of GAG oligosaccharides by Jacquinet,49, 50 Jan Boons,51 Seeberger,52 and others53, 54 have decreased the number of synthetic steps, increased stereocontrol and enhanced yields, each new target still represents a .

parallel synthesis of a new class of glycodendrimers by Martin McWatt Download PDF EPUB FB2

The defined location of the compound in the array provides the structure of the compound. A commonly used format for parallel synthesis is the well microtiter plate, and, today, combinatorial libraries comprising hundreds to thousands of compounds can be synthesized by parallel synthesis, often in an automated fashion.

Parallel Synthesis is a technique widely used by researchers to speed the discovery of new compounds and screen for optimal process conditions. Home By Application AutoChem Applications Parallel Synthesis and Screening of Reaction Conditions.

A New Synthesis Lab. Modular Liquid-Phase Parallel Synthesis of a Highly Diverse Ligand Library. Synthesis of a New Class of β-Iodo N-Alkenyl 2-Pyridones. Sarah Z. Tasker, Benjamin M. Brandsen, Keun Ah Ryu, Gregory S. Snapper, Richard J.

Staples, Roger L. DeKock, and Carolyn E. Anderson. Combinatorial Chemistry 1. Library synthesis a) in solution, parallel synthesis b) on solid support c) split and combine, one bead one compound 2. Deconvolution and Tagging 3. Dynamic Combinatoric Chemistry diversification reaction diversification reaction divide Parallel Library Synthesis • 12 reactions provide 9 compounds • The.

Parallel and orthodox synthesis is compared below. Orthodox synthesis usually involves a multistep sequence, e.g. from A through to the final product D, which is purified and fully characterised before screening.

The next analogue is then designed, guided by the biological activity of the previous compound, prepared, and then screened. We have developed methods for the parallel synthesis of two libraries of non-carbohydrate-based analogues of mannose on a solid support.

The natural product shikimic acid was used as a key. Methods of Combinatorial Chemistry. The second method is called "parallel synthesis". All the different chemical structure combinations are prepared separately, in parallel, using thousands of reaction vessels and a robot programmed to add the appropriate reagents to each one.

This method is unsuitable for the creation of very diverse. Sep 29,  · Combinatorial chemistry 1. by (chemistry) 2. •Combinatorial Chemistry is a new method developed by academics and researchers to reduce the time and cost of producing effective, marketable and competitive new drugs.

The last two sections introduce recent attempts to use carbosilane glycodendrimers as new versatile and widely-applicable lectin sensors, and the use of carbosilane glycodendrimers as a novel drug.

Type Synthesis of Parallel Mechanisms (Springer Tracts in Advanced Robotics) [Xianwen Kong, Clément M. Gosselin] on *FREE* shipping on qualifying offers. This unique monograph focuses on the systematic type synthesis of parallel mechanisms (PMs), a key issue in the creative design of a wide variety of innovative devices such as parallel manipulatorsAuthor: Xianwen Kong.

Aug 23,  · Glycodendrimers have become valuable tools in glycobiology especially in the context of multivalency which is an important principle of carbohydrate-protein interactions.

Multivalency effects observed in glycobiology are being currently discussed controversially and a conclusive understanding of this phenomenon has not yet been obtained.

Nov 29,  · A solid phase carbohydrate library was synthesized and screened against Bauhinia purpurea lectin. The library, which contains approximately di- and trisaccharides, was synthesized with chemical encoding on TentaGel resin so that each bead contained a single carbohydrate. Two ligands that bind more tightly to the lectin than Gal-β-1,3-GalNAc (the known ligand) have been.

Apr 19,  · Parallel synthesis 1. By: Satyendra yadav 2. Parallel synthesis leads to a discrete library by simultaneous addition of reactants in different reaction vessels and parallel handling of each library sample. Parallel synthesis is a method by which library construction occurs in distinct spaces on an array, such that each member of a library is defined by its position on that array.

All three isomers (ortho, meta, and para) of []cyclophane bearing 1,6-dioxahexa-2,4-diyne bridges have been synthesized and structually characterized by single-crystal X-ray crystallography to determine the conformation of the cyclophanes and their cavity dimensions.

The three isomeric []cyclophanes bearing 1,4-dioxabutyne bridges have also been synthesized from butyne-1,4-diol Cited by: Glycodendrimers: versatile tools for nanotechnology René Roy1,*, Tze Chieh Shiao1, Kate Rittenhouse-Olson2 1PharmaQAM - Department of Chemistry, Université du Québec à Montréal, Montréal, QC, Canada, 2Department of Biotechnical and Clinical Laboratory Sciences, University of Buffalo, Buffalo, NY, United States of America.

Title: Biocompatible Carbon Nanotubes Generated by Functionalization with Glycodendrimers This work was supported by the Director, Office of Energy Research, Office of Basic Energy Sciences, Division of Materials Sciences, of the U.S.

Department of Energy under Contract No. DE-ACSF, within the Interfacing Nanostructures Initiative and NIH (K99M). Oct 19,  · Once synthesized, all of the sulfated sialic acid-PAMAM glycodendrimers could be assessed for anti-HIV-1 activity by two separate, yet complementary assays.

The first assay, a fast ELISA (enzyme-linked immunosorbent assay) developed in our lab, could be used to Cited by: Reductive amination, Alkylation / deprotection / alkylation. Jan 21,  · Hexaphenylbenzene as a Rigid Template for the Straightforward Syntheses of “Star-Shaped” Glycodendrimers.

the straightforward preparation of a new family of multivalent glycosylated architectures built around a more rigid we have developed an expeditive and systematic route toward the synthesis of original glycoclusters and G(1 Cited by: Synthesis, self-assembly and response of glycodendrimers.

Cryo-TEM confirming the formation of glycodendrimersomes. Dendrimers are branched molecules of precise chemistry, and Janus-dendrimers are dendrimers that have two distinct faces, with unique chemistry corresponding to each face.

Synthesis of these materials is the first step in the. Start studying NASM CH 4 - Exercise Metabolism and Bioenergetics Q's. Learn vocabulary, terms, and more with flashcards, games, and other study tools. Thiol‐ene and thiol‐yne‐based synthesis of glycodendrimers as nanomolar inhibitors of wheat germ agglutinin The eight glycodendrimers were excellent ligands showing IC 50 values in the nanomolar range and relative an email within 10 minutes, your email address may not be registered, and you may need to create a new Wiley Online.

Search term. Advanced Search Citation Search. Search term. Zhang, Y.-H.; Gao, Z.-X.; Zhong, C.-L.; Zhou, H.-B.; Chen, L.; Wu, W.-M.; Peng, X.-J.; Yao, Z.-J. An Inexpensive Fluorescent Labeling Protocol for Bioactive.

We have developed methods for the parallel synthesis of two libraries of non-carbohydrate-based analogues of mannose on a solid support. The natural product shikimic acid was used as a key building block. The ability of the compounds to block the binding of the C-type lectin MBP-A to a mannosylated surface was assessed in a high-throughput assay.

Both most common chemical ligations and chemoenzymatic synthesis will be outlined. Finally, the synthesis of “smart” glycodendrimers and glycoclusters' newer generation involving rapid covalent assembly of sugars by transition metal catalyzed cross-coupling reactions using Cited by: AutoMATE multi-reactor system.

Chemistry platforms with independently controlled zones, offering both high and low pressure solutions. Options of 2, 4, 6 or 8 zones available, with the facility to mix and match up to 8 different reactors and vials, low and high pressure. The fundamental building blocks of this new polymer class are referred to as “dendrimers”.

More than two decades later, inin their paper “New insight into the interactions between dendrimers and surfactants ” Cheng and co-authors proposed a new drug formulation based on dendrimer by: Glycodendrimers have advantageous characteristics of providing potent immunostimulating and adjuvant properties in vaccine preparation due to their molecularly defined multivalent scaffolds together with their abundant architectural variations.

Their versatile syntheses allow the production of highly defined conjugates with small overview of the use of dendrimers as carriers of. Design, Synthesis and Evaluation of Glycodendrimers as Multivalent Ligands Ontwerp, synthese en evaluatie van glycodendrimeren als multivalente liganden (met een samenvatting in het Nederlands) concerning new resins, linkers, protecting groups and glycosylating reagents.

groups. The glycodendrimer products were collected as described above. The synthesis for each conjugates was performed for times. Chemical analysis of PAMAM-HYD and glycodendrimers Electronic Supplementary Material (ESI) for Polymer Chemistry This journal is ' The Royal Society .A dendrimer is a synthetically made branched molecule.

In this work, a family of amphiphilic Janus dendrimers bearing precise carbohydrate residues arranged in a defined sequence – glycodendrimers – were used to make vesicles that could be agglutinated by .Different techniques in combinatorial and solid phase chemistry presented by: Dominik Göddertz.

Table of contents • Multiple solid phase peptide synthesis MPS • Multipin-Technique • Tea-Bag Method • Parallel libraries • Light-directed spatially addressable parallel chemical synthesis • Spot synthesis • Coupling of compound mixtures.